Imbali yokusetyenziswa kwe-ginseng kwiMpilo kunye neMithi

Intshayelelo

I-ginseng kudala ihlonishwa njengenye yezona zityalo zinamandla kunye nenkcubeko ebalulekileyo kumayeza esintu. Ngemvelaphi yayo etyebileyo yembali kunye nokubaluleka okukhulayo kwisayensi yezempilo yanamhlanje, iginseng iye yavela kwingcambu engaqondakaliyo yaya kwindlu yamandla esebenzayo. Namhlanje, uphuhliso lweiipeptide zeginsengimele umda omtsha kwisondlo esisebenzayo, siphucula iinzuzo zemifuno ngokusebenzisa ubuchule bokukhupha obuphambili [1].

Imvelaphi kunye neengcambu zeNkcubeko zeGinseng

Igama"Panax"lithatyathwe kwigama lesiGrike elithetha “ukuphilisa konke,” nto leyo ebonisa imbono yamandulo yeginseng njengonyango lwendalo iphela. Usetyenziso olurekhodiweyo lwakuqala lwePanax ginsengisukela emva kwiminyaka eyi-2,000 e-China, apho yayixabiswa ngokukwazi kwayo ukubuyisela amandla kunye nokunyanga izifo ezahlukeneyo [2]. EKorea, iginseng yasendle yayigqalwa njengobutyebi belizwe, edla ngokugcinelwa abantu basebukhosini. Ngeli xesha, abantu bomthonyama baseMelika basetyenziswaI-Panax quinquefolius, okanye i-ginseng yaseMelika, ngenxa yeziphumo zayo zokuzola kunye nokomeleza.

Ukutyhubela iinkulungwane, i-ginseng yazinziswa nzulu kwizithethe zenkcubeko kunye neenkqubo zonyango, ebonisa ubomi obude, amandla kunye nokulinganisela. Ngelixa ngokwesiko kutyiwa njengeengcambu okanye i-decoctions, uphando lwangoku luchonge iikhompawundi ezithile ezisebenzayo, ezinje ngeginsenosides kunye neepeptides, ezinoxanduva lweziphumo zonyango lwazo [3].

I-Ginseng kwiiNkqubo zoNyango zesiNtu

Kwiyeza lesiNtu laseTshayina (TCM), i-ginseng ihlelwa njengemifuno ephezulu esetyenziselwa ukuqinisa iQi, ukuqinisa udaka, kunye nokuxhasa ukusebenza kwemiphunga. Imixube yemifuno efanaRen Shen TangkwayeUGu Pi Tanggxininisa indima yayo esisiseko ekubuyiseleni amandla kunye nokukhuthaza ukuvisisana kwangaphakathi.

EKorea naseJapan, iginseng ikwasisiseko sokwenza amayeza. I-ginseng ebomvu yaseKorea, ecutshungulwa ngokutshisa kunye nokomisa, ixabiseke kakhulu ngenxa yokwandisa amandla ayo. Kwiyeza laseJapan leKampo, iginseng iyaqhubeka isisithako esibalulekileyo kwiifomula eziyilelwe ukuphucula ukomelela kunye nokusebenza kwe-metabolic.

Ezi zicelo zemveli zabeka isiseko sezinto ezintsha zale mihla ezifana ne-ginseng peptides, ebeka yodwa kwaye igxile kwezona ziqhezu zemolekyuli ze-bioactive kwiziphumo zempilo ekujoliswe kuzo [4].

UFundo lweNzululwazi kunye neMixholo eSebenzayo

I-Ginseng iqulethe uluhlu oluyinkimbinkimbi lwezinto ezisebenzayo, kuquka i-ginsenosides, i-polysaccharides, kunye ne-oyile ebalulekileyo. Kumashumi eminyaka akutshanje, izazinzulu ziye zafumanisa kwaye zafunda i-ginseng peptides-iiproteni ezimfutshane ezifunyenwe nge-enzymatic hydrolysis yeengcambu zeginseng.

Iipeptide zeGinseng zahlukile kwizicatshulwa zemveli kwi-bioavailability yazo ephuculweyo kunye nozinzo. Iveliswe ngeenkqubo ze-enzymatic, ezi peptides zigcina isiseko sepropathi ye-ginseng ye-pharmacological ngelixa inikezela ngeziphumo ezijolise ngakumbi zomzimba [5].

Uphononongo lubonise ukuba i-ginseng peptides ibonisa i-antioxidant, anti-inflammatory, neuroprotective, kunye ne-immune-regulatory activities. Ezi zakhiwo zibenza bafanelekele uluhlu lwezicelo, ukusuka kukutya okusebenzayo ukuya kwisondlo seklinikhi [6].

Izicelo zanamhlanje kwiMpilo kunye neZondlo

I-Ginseng ifumene ubomi obutsha kwi-nutraceuticals yanamhlanje kunye neziselo ezisebenzayo ezijoliswe ekuphuculeni amandla kunye nokusebenza kwengqondo. Ukongezwa kwe-ginseng peptides kwezi mveliso kukhokelele ekuphuculeni ukusebenza kakuhle, ngakumbi ekulweni nokudinwa kunye nokukhuthaza ukucaca kwengqondo [7].

Iipropathi zabo ze-adapogenic nazo zenza i-ginseng peptides isebenze ekuxhaseni ukomelela koxinzelelo kunye nokulungelelana kwamajoni omzimba. Izifundo zenzululwazi ziye zabonisa amandla abo okulungelelanisa amanqanaba e-cortisol, ukwandisa umbulali wendalo (NK) umsebenzi weeseli, kunye nokunciphisa ukuvuvukala [8].

Ngaphaya koko, iipeptide zeginseng ziye zavela njengeearhente ezichasene nokuguga. Ngokukhusela umsebenzi we-mitochondrial kunye nokukhuthaza ukuhlanganiswa kwe-collagen, baxhasa impilo yolusu, ibhalansi ye-metabolic, kunye namandla onke [9].

Uphuhliso loShishino lweHlabathi

I-China, iKorea, kunye ne-United States ngabavelisi abahamba phambili be-ginseng, kunye neendawo ezizinikeleyo zokulima kunye nokusebenza okuphezulu. Ukuveliswa kweepeptide zeginseng kufuna iziseko zophuhliso ezikhethekileyo zebhayoloji ukuqinisekisa ukungaguquguquki kwe-enzymatic kunye nokugcinwa kwezinto eziphilayo.

Imarike yeemveliso ezisekwe kwi-ginseng peptide ikhula ngokukhawuleza. Ezi peptides ngoku zibandakanyiwe kwizongezo zomgubo, iishoti ezilungele ukusela, kunye neengxowa ezijolise kubathengi abakhathalela impilo. Kwicandelo le-B2B, izithako ze-ginseng zepeptide zifunwa kakhulu kwimixube esebenzayo [10].

Amaqumrhu olawulo lwehlabathi jikelele afana ne-EFSA kunye ne-CFDA ngokuthe ngcembe aqaphela iipeptide eziphuma kwi-ginseng, ngelixa ukusungulwa kwezinto ezintsha kuqhubeka ngokuxutywa kwelungelo elilodwa lomenzi wechiza kunye nolingo lwezonyango olujolise ekuboniseni izibonelelo zabo zokusebenza [11].

Iipeptide zeGinseng: Umda wale mihla

I-Ginseng peptides imele inkqubela phambili kwi-herbal biotechnology. Ezi peptides ezinobunzima obuphantsi bemolekyuli ziphuma kwiiproteni zeengcambu zeginseng nge-enzymatic hydrolysis, izenza kube lula ukuba umzimba uzifunxe kwaye uzisebenzise.

Iindlela zabo zebhayoloji ziquka ukumodareyithwa koxinzelelo lwe-oxidative, ukuphuculwa kokulungiswa kwamaselula, kunye nokulawulwa kwamajoni omzimba. Xa kuthelekiswa nezicatshulwa ezikrwada, i-ginseng peptides ibonisa ukunyibilika okuphezulu, ukufunxa, kunye nesenzo esijolisekileyo, ukuzibeka njengezithako zeprimiyamu kwisizukulwana esilandelayo se-nutraceuticals [12].

Imingeni kunye neengxabano

Ngaphandle kweempawu ezininzi ezithembisayo ze-ginseng kunye neepeptide zayo, ishishini lijongene nemingeni efana nokukrexeza, ukungangqinelani komgangatho, kunye nokungabikho kokuqinisekiswa okufanayo kweklinikhi. Ayizizo zonke iimveliso kwimarike eziqulethe amanqanaba aqinisekisiweyo ngokwesayensi yeekhompawundi ezisebenzayo, kwaye ulwazi lwabathengi luhlala lulinganiselwe [13].

Iinzame ziyaqhubeka ukulinganisa umgangatho we-ginseng peptide, ukuphucula iindlela zovavanyo lwezonyango, kunye nokuphuhlisa izikhokelo zolawulo zehlabathi ezinokuqinisekisa zombini ukusebenza kunye nokhuseleko.

Ikamva elizayo

Ikamva le-ginseng ilele kwisondlo esichanekileyo, apho i-ginseng peptides iya kudlala indima ebalulekileyo kwizisombululo zempilo zomntu. Izinto ezintsha ezifana ne-nanocarriers, ukukhutshwa okuzinzileyo, kunye ne-synergy nezinye i-bioactives kunokwenzeka ukuba zikhulise ukufikelela kunyango lweepeptides ze-ginseng.

Ngapha koko, njengoko abathengi befuna izisombululo zendalo, ezixhaswa bubungqina bamandla, ukwaluphala, ukunganyangeki, kunye nokusebenza kwengqondo, i-ginseng peptides iya kuba yinxalenye yeendlela zempilo zanamhlanje [14].

Ukuqukumbela

Ukusuka kwindima yayo engcwele kunyango lwakudala ukuya kwimeko yayo yokuvela njenge-peptide esebenzayo, i-ginseng iyaqhubeka nokukhuthaza kwaye iguquke. Ukunyuka kwe-ginseng peptides kuphawula utshintsho oluguquguqukayo, luvumela izibonelelo zempilo ezinzulu ngesayensi yanamhlanje ngaphandle kokuphulukana neengcambu zemveli.

Iimbekiselo

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• [9] UKim HJ, et al.Imiphumo yokuguga ye-ginseng peptides: ukukhuselwa kweMitochondrial kunye nokuvuselelwa kwesikhumba.
• [10] Lee SM.Intsingiselo yentengiso kunye nokuveliswa kwe-ginseng peptides.
• [11] Zhang Y, et al.Uvavanyo lweklinikhi ye-ginseng peptides ekudinweni nasekukhuseleni.
• [12] Chen L, et al.Uhlalutyo lwesakhiwo kunye ne-bioactivities yeepeptides eziphuma kwi-ginseng.
• [13] uLi W, et al.Imingeni ekumiseleni amalungiselelo e-ginseng.
• [14] Gao Y, et al.Ukubanakho kwe-ginseng peptides kwisondlo somntu.